Molecular and Industrial Biotechnology group. GBMI

Kristina Ivanova contributions

Scientific contributions


Peer reviewed publications
      • Ivanova K, Ramon E, Wnorowska U, Todorova K, Ivanova A, Bastos-Arrieta J, Puertas-Segura A, Deptula P, Damyanova T, Paunov-krasteva T, Bucki R, Ivanov I and Tzanov T. Integrated Biofilm Dispersion and Virulence Responsiveness for Targeted Treatment of Pseudomonas aeruginosa Infection in Lungs. Advanced Functional Materials, 2024.  https://doi.org/10.1002/adfm.202402868
      •  Puertas-Segura A, Ivanova K, Ivanova A, Ivanov I, Todorova K, Dimitrov P, Ciardelli G and Tzanov T. Mussel-Inspired Sonochemical Nanocomposite Coating on Cartheters for Prevention of Urinary Infections. ACS Applied Materials & Interfaces. 2024. https://doi.org/10.1021/acsami.4c05713
      • Carvalho E, Fernandes M, Ivanova K, Rodríguez-Lejarraga P, Tzanov T, Ribeiro C and Lanceros-Mendez S. Multifunctional piezoelectric surfaces enhanced with layer-by-layer coating for improved osseointegration and antibacterial performance. Colloids and surfaces B: Biointerfaces, 2024  https://doi.org/10.1016/j.colsurfb.2024.114123
      • Puertas-Segura A, Morena A G, Pérez-Rafael S, Ivanova K, Ivanov I, Todorova K, Dimitrov P, Ciardelli G and Tzanov T. Enzymatically Built Nanoenabled Antimicrobial Coating on Urinary Catheters. ACS Applied Materials & Interfaces. 2024 https://doi.org/10.1021/acsami.4c08599
      • Puertas-Segura A, Ivanova K, Ivanova A, Ivanov I, Todorova K, Dimitrov P, Ciardelli G and Tzanov T.  Mussel-inspired sonochemical nanocomposite coating on catheters for prevention of urinary infections. ACS Applied Materials & Interfaces. 2024  https://doi.org/10.1021/acsami.4c05713
      • Perelshtein I, Shoshani S, Jacobi G, Natan M, Dudchenko N, Perkas N, Tkachev M, Bengalli R, Fiandra L, Mantecca P, Ivanova K, Tzanov T, Banin E, Gedanken A. Protecting the Antibacterial Coating of Urinal Catheters for improving Safety. ACS Appl. Bio Mater, 2024. https://doi.org/10.1021/acsabm.3c00988
      • Ferreres G, Ivanova K, Torrent-Burgués J, Tzanov T. Multimodal silver-chitosan-acylase nanoparticles inhibit bacterial growth and biofilm formation by Gram-negative Pseudomonas aeruginosa bacterium. Journal of Colloid and Interface Science, 2023. https://doi.org/10.1016/j.jcis.2023.04.184
      • Ferreres G, Ivanova K, Ivanov I, Tzanov T.  Nanomaterials and Coatings for Managing Antibiotic-Resistant Biofilms. Antibiotics 2023,  https://doi.org/10.3390/antibiotics12020310
      • Ivanova K, Ramon E, Ivanova A, Sanchez-Gomez S, Tzanov T. Bio-Based Nano-Enabled Cosmetic Formulations for the Treatment of Cutibacterium Acnes-Associated Skin Infections. Antioxidants 2023,  https://doi.org/10.3390/antiox12020432
      • Fernandes M, Carvalho E, Correia D, Esperança J, Padrao J, Ivanova K, Hoyo J, Tanov T, Lanceros-Mendez S. Ionic Liquids as Biocompatible Antibacterial Agents: A Case Study on Structure-Related Bioactivity on Escherichia coli. ACS Applied Materials & Interfaces, 2022. https://pubs.acs.org/doi/10.1021/acsabm.2c00615
      • Bermeo L, Ivanova K, Pérez, L M, Forés E, Pérez-Rafael S, Casas-Zapata J C C, Morató J, Tzanov T. Sono-Enzymatically Embedded Antibacterial Silver-Lignin Nanoparticles on Cork Filter Material for Water Disinfection. International Journal of Molecular Sciences. 2022, 23, 11679. https://doi.org/10.3390/ijms231911679.
      • Ivanova K, Ivanova A, Hoyo J, Pérez-Rafael S, Tzanov T. Nano-Formulation Endows Quorum Quenching Enzyme-Antibiotic Hybrids with Improved Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa. International Journal of Molecular Sciences. 2022, https://doi.org/10.3390/ijms23147632.
      • Ivanova A, Ivanova K, Fiandra L, Mantecca P, Catelani T, Natan M, Banin E, Jacobi G, and Tzanov T. Antibacterial, Antibiofilm, and Antiviral Farnesol-Containing Nanoparticles Prevent Staphylococcus aureus from Drug Resistance Development. International Journal of Molecular Sciences. 2022, https://doi.org/10.3390/ijms23147527
      • Ivanova A, Ivanova K, and Tzanov T. Simultaneous ultrasound-assisted hybrid polyzwitterion/antimicrobial peptide nanoparticles synthesis and deposition on silicone urinary catheters for prevention of biofilm-associated infections. Nanomaterials, 2021, http://doi.org/10.3390/nano11113143
      • Ivanova A, Ivanova K, Perelshtein I, Gedanken A, Todorova K, Milcheva R, Dimitrov P, Popova T, Tzanko T. Sonochemically Engineered Nano-enabled Zinc Oxide/Amylase Coatings Prevent the Occurrence of Catheter-Associated Urinary Tract Infections. Materials Science & Engineering C 2021.   doi: 10.1016/j.msec.2021.112518
      • Slavin Y N, Ivanova K, Tang W, Tzanov T, Li S, Bach H. Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents. Nanomaterials 2021, 10.3390/nano11081984.
      • Pérez-Rafael S, Ivanova K, Stefanov I, Puiggalí J, del Valle L J, Todorova K, Dimitrov P,  Hinojosa-Caballero D, Tzanov, T. Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment. Acta Biomaterialia 2021, https://doi.org/10.1016/j.actbio.2021.07.020.
      • Slavin Y N, Ivanova K, Hoyo J, Perelshtein I, Owen G, Haegert A, Lin Y, LeBihan S, Gedanken A, Häfeli U O, Tzanov T, Bach H. Novel Lignin-Capped Silver Nanoparticles against MultidrugResistant Bacteria, ACS Applied Materials & Interfaces 2021, https://doi.org/10.1021/acsami.0c16921.
      • Ferrer-Vilanova A, Alonso Y, Dietvorst J, Pérez-Montero M, Rodriguez R, Ivanova K, Tzanov T, Vigues N, Mas J, Guirado G, Muñoz-Berbel X. Sonochemical Coating of Prussian Blue for the Production of Smart Bacterial Sensing Hospital Textiles, Ultrasonics Sonochemistry 2020, 10.1016/j.ultsonch.2020.105317.
      • Ivanova K, Ivanova A, Ramon E, Hoyo J, Sanchez-Gomez S, Tzanov T. Antibody-Enabled Antimicrobial Nanocapsules for Selective Elimination of Staphylococcus aureus. ACS Applied Materials & Interfaces 2020, http://dx.doi.org/10.1021/acsami.0c09364.
      • Hoyo J, Ivanova K, Torrent-Burgués J, Tzanov T. Interaction of Silver-Lignin Nanoparticles With Mammalian Mimetic Membranes. Frontiers in Bioengineeringand Biotechnology 2020,  https://doi.org/10.3389/fbioe.2020.00439. 
      • Ivanova A, Ivanova K, Tied A, Heinze T, and Tzanov T. Layer-by-Layer Coating of Aminocellulose and Quorum Quenching Acylase on Silver Nanoparticles Synergistically Eradicate Bacteria and Their Biofilms. Advanced Functional Materials 2020, https://doi.org/10.1002/adfm.202001284.
      • Ruseva K, Ivanova K, Todorova K, Vladov I, Nanev V, Tzanov T, Hinojosa-Caballero D, Argirova M, Vassileva E. Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings. European Polymer Journal 2020, doi: https://doi.org/10.1016/j.eurpolymj.2020.109673.
      • Morena A. Gala, Stefanov I, Ivanova K, Pérez-Rafael S, Sánchez-Soto M, Tzanov T. Antibacterial Polyurethane Foams with Incorporated Lignin-Capped Silver Nanoparticles for Chronic Wound Treatment. Industrial and Engineering Chemistry Research 2020, doi: https://doi.org/10.1021/acs.iecr.9b06362.
      • Ruseva K, Ivanova K, Todorova K, Gabrashanska M, Hinojosa-Caballero D, Tzanov T, Vassileva E. Poly(sulfobetaine methacrylate)/poly(ethylene glycole) hydrogels for chronic wounds management, European Polymer Journal 2019, doi: https://doi.org/10.1016/j.eurpolymj.2019.05.022.
      • de la Escosura-Muñiz A, Ivanova K, Tzanov T. Electrical evaluation of bacterial virulence factors using nanopores. ACS Applied Materials & Interfaces 2019, doi: 10.1021/acsami.9b02382.
      • Hoyo J, Ivanova K, Guaus E, Tzanov T. Multifunctional ZnO NPs-chitosan-gallic acid hybrid nanocoating to overcome contact lenses associated conditions and discomfort. Journal of Colloids and Interface Science, 2019, https://doi.org/10.1016/j.jcis.2019.02.043.
      • Francesko A, Ivanova K, Hoyo J, Pérez-Rafael S, Petkova P, Fernandes M M, Heinze T, Mendoza E, Tzanov T. Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films, Biomacromolecules 2018, doi: 10.1021/acs.biomac.8b00626.
      • Bassegoda A, Ivanova K, Ramon E, Tzanov T. Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials. Applied Microbiology and Biotechnology 2018, doi:10.1007/s00253-018-8776-0, http://rdcu.be/F6jE.

      • Ivanova A, Ivanova K, Hoyo J, Heinze T, Sanchez-Gomez S, Tzanov T. Layer-by-layer decorated nanoparticles with tunable antibacterial and antibiofilm properties against both gram-positive and gram-negative bacteria. ACS Applied Materials & Interfaces 2018, doi: 10.1021/acsami.7b16508.

      • Fernandes M M, Ivanova K, Hoyo J, Pérez-Rafael S, Francesko A, Tzanov T. "Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria." ACS Applied Materials & Interfaces, 2017, doi: 10.1021/acsami.7b00217.
      • Ivanova K, Ramon E, Hoyo J, Tzanov T. “Innovative Approaches for Controlling Clinically Relevant Biofilms: Current Trends and Future Prospects. Current Topics in Medicinal Chemistry, 2017, doi: 10.2174/1568026617666170105143315. 
      • Fernandes M M, Ivanova K, Francesko A, River D, Torrent-Burgués J,   Gedanken A,  Mendonza E, Tzanov T.  "Escherichia coli and Pseudomonas aeruginosa eradication by nano-penicillin G." Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12, 2061-2069, doi:10.1016/j.nano.2016.05.018
      • Francesko A, Fernandes M M, Ivanova K, Amorim S, Reis R L, Pashkuleva I, Mendoza E, Pfeifer A, Heinze T, Tzanov T. "Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters", Acta Biomaterialia, 2016, http://dx.doi.org/10.1016/j.actbio.2016.01.020
      • Ivanova K, Fernandes M M, Francesko A,Guezguez J, Burnet M, Mendonza E, Tzanov T. "Quorum quenching and matrix degrading enzymes in multilayer coatings synergistically prevent bacterial biofilm formation on urinary catheters", ACS Applied Materials & Interfaces, 2015, DOI: 10.1021/acsami.5b09489, http://pubs.acs.org/articlesonrequest/AOR-C2ftuuKenNNQY6f4kPSS.
      • Ivanova K, Fernandes M M, Mendonza E, Tzanov T. "Enzyme multilayer coatings inhibit Pseudomonas aeruginosa biofilm formation on urinary catheters", Applied Microbiology and Biotechnology, 2015, DOI: 10.1007/s00253-015-6378-7.
      • Thallinger B, Brandauer M, Burger P, Sygmund C, Ludwig R, Ivanova K, Kun J, Scaini D, Burnet M, Tzanov T,  Nyanhongo G, Guebitz G. "Cellobiose dehydrogenase functionalized urinary catheter as novel antibiofilm system", Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015, DOI: 10.1002/jbm.b.33491.
        Book chapters
          • Morena A G, Ferreres G, Ivanova K, Pérez-Rafael S, Tzanov T, Antimicrobial Lightweight Materials and Components, in “Advanced Lightweight Multifunctional Materials” edited by Costa P, Costa C, and Lanceros-Mendez S, ISBN: 978-0-12-818501-8, Elsevier, 2020, 469-502.
          • Ivanova A, Ivanova K, Tzanov T, Inhibition of Quorum-Sensing: A New Paradigm in Controlling Bacterial Virulence and Biofilm Formation, in "Biotechnological Applications of Quorum Sensing Inhibitors",  edited by Kalia, VC,  ISBN: 978-981-10-9026-43-21, Springer, Singapore, 2018, 3-21.
          • Ivanova K, Bassegoda A, Tzanov T. Antibacterial Coatings on Medical Devices, in " Handbook of Antimicrobial Coating", edited by Tiwari, A, ISBN: 978-0-12-811982-2, Elsevier Inc., USA, 2018, 487-509.
          • Ivanova K, Fernandes MM, Tzanov T. Strategies for silencing bacterial communication, in "Quorum sensing vs quorum quenching: a battle with no end in sight", edited by Kalia, VC, Springer India, 2015.
          • Ivanova K, Fernandes MM, Tzanov T. Current advances on bacterial pathogenesis inhibition and treatment strategies, in "Microbial pathogens and strategies for combating them: science, technology and education", edited by Mendez-Vilas, A, Formatex Research Center, 2013.
          Patents
          • Dos Santos Marinho Da Silva C. J., Alves De Ornelas Cardoso M. I., Gomes Ribeiro, A. C., Gonçalves Nobre C., Correia Coelho D. S., Tzanov T., Ivanova K., Ramon Portes E., Gryshchuk L., Grishchuk S. PCT/IB2020/059168 (2020), Capsule for functionalizing a product, method and uses thereof.

          • Pérez Rafael S., Ivanova K., Ferreres Cabanes G., Morena A G., Tzanov T. EP20383150.8 (2020), Method to produce in situ self-assembled multifunctional nanocomposite hydrogel and its uses thereof.

           Communications to meetings

          • Puertas-Segura A, Ivanova A, Ivanova K, Ciardelli G, Tzanov T. “Ultrasound-assisted nano-enabled hydrogel coating on urinary catheters for prevention of biofilm-associated infections” (oral), ACS National Meeting & Exposition, March 2023, Indianapolis, Indiana (USA) 

          • Ivanova K, Tzanov T. “Sonochemical-enzymatic coating of medical textiles with antibacterial nanoparticles” (oral), NanoInovation 2017 Conference and exhibition, September 26-29, 2017, Italy (Rome)

          • Ivanova A, Ivanova K, Hoyo J, Heinze T, and Tzanov T. "Layer-by-Layer decorated nanoparticles: an efficient antibacterial and antibiofilm agent" (oral), Designer Biology: from proteins and cells to scaffolds and materials, June 7-9, 2017, Vienna (Austria)

          • Ivanova K, Ivanova A, Hoyo J, Tzanov T. “Hybrid nanocoatings of quorum quenching enzyme and antibiotic for prevention of bacterial biofilms” (oral), 2nd International Caparica Conference in Antibiotic Resistance,  June 12-15, 2017, Caparica (Portugal)
          • Ivanova K, “Pilots for production of surface nano-structured antimicrobial and anti-biofilm materials” (oral), Polymer Replication on Nanoscale, 4th International Conference, 8-9 May 2017 Aachen, (Germany)

          • Ivanova K, Ivanova A, Heinze T, Tzanov T. “Antibacterial Layer-by-Layer coating of nanoparticles” (poster), 253rd American Chemical Society National Meeting & Exposition, April 2017, San Francisco (USA)

          • Ruseva K, Ivanova K, Vasileva Е, Tzanov T. " Zwitterionic polymers for  chronic wound  management"(poster), 253rd American Chemical Society National Meeting & Exposition, April 2017, San Francisco (USA)

          • Ivanova K, Ivanova A, Heinze T, Tzanov T. “Antibacterial Layer-by-Layer coating of nanoparticles” (poster), 253rd American Chemical Society National Meeting & Exposition, April 2017, San Francisco (USA)

          • Tzanov T, Petkova P, Ivanova K, Slavin N, Bach H, Stefanov I. “Biopolymer hydrogels embedded with lignin-silver nanocomposites with broad activity against antibiotic-resistant clinical isolates” (poster), 253rd American Chemical Society National Meeting & Exposition, April 2017, San Francisco (USA)

          • Ivanova K, Hoyo, J, Tzanov T. "Hybrid nano-antibacterials to control biofilm-associated infections" (poster), 253rd American Chemical Society National Meeting & Exposition,  April 2017, San Francisco (USA)
          • Hoyo J, Ivanova K, Fernandes M, Francesko T, Tzanov T. "Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria" (poster), 253rd American Chemical Society National Meeting & Exposition, April 2017, San Francisco (USA)

          • Tzanov T, Ivanova K, Petkova P, Ramon E, Fernandes M, Blanco C, "Antibacterial approaches from materials engineering perspective – enzymes on work" (oral), 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego (USA)

          • Ivanova K, Metieva M, Tzanov T. "Enzymatically-crosslinked multilayer antioxidant/nanoantibiotic coatings for prevention of bacterial biofilms" (oral), 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego (USA)
          • Ivanova K, Fernandes MM, Francesko A, Tzanov T. “Alternative approaches for prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters“ (oral), The international chemical congress of pacific basin societies (PACIFICHEM), December 15-20, 2015, Honolulu, Hawaii (USA)
          • Ivanova K, Fernandes MM, Francesko A, Tzanov T. “Quorum quenching and matrix degrading enzymes in multilayer coatings prevent bacterial biofilm formation on urinary catheters“ (oral), Conference 2015 Advances in Functional Materials, June 29 - July 3, 2015, Stony Brook (USA)
          • Ivanova K, Fernandes MM, Tzanov T. "Sonochemical coatings of acylase nanoparticles inhibit Pseudomonas aeruginosa biofilm formation and virulence factors production" (oral), International Symposium on Quorum Sensing Inhibition, June 3-5, 2015, Santiago de Compostela (Spain)
          • Ivanova K, Fernandes MM, Francesko A, Tzanov T. “Enzyme multilayer coatings prevent bacterial biofilm formation on urinary catheters“ (oral), 249th ACS National Meeting & Exposition, March 22-26, 2015, Denver (USA)
          • Fernandes MM, Ivanova K, Francesko A, Tzanov T. “Convectional antibiotics in form of nanospheres prevent biofilm formation and provide infection control” (oral), III International Conference on Antimicrobial Research (ICAR 2014), October 1-3, 2014, Madrid (Spain)
          • Ivanova K, Fernandes MM, Tzanov T. "Enzyme-based nanoparticles to inhibit bacterial biofilm formation in urinary catheters" (oral), 8th International Conference on Polymer and Fiber Biotechnology (IPFB 2014), May 25-27, 2014, Braga (Portugal)
          • Rocasalbas G, Ivanova K, Petkova P, Tzanov T. "Solid-liquid surface functionalization of biopolymeric platforms with plant-derived polyphenols" (poster), 245th ACS National Meeting, April 07-11, 2013, New Orleans (USA)
          • Ivanova K, Fernandes MM, Tzanov T. "Enzymes to control bacterial biofilm formation" (poster), 245th ACS National Meeting, April 07-11, 2013, New Orleans (USA)
          • Ivanova K., Fernandes MM., Tzanov T. "Enzymatic-induced degradation of bacterial biofilms" (oral),  E-MRS 2012 Fall Meeting, September 17-21, 2012, Warsaw (Poland)

           Awards

          • Best student oral communication to the contribution entitled "Sonochemical coatings of acylase nanoparticles inhibit Pseudomonas aeruginosa biofilm formation and virulence factors production", I International Symposium on Quorum Sensing Inhibition, June 3-5, 2015 , Santiago de Compostela (Spain)